The cellular protein hnRNP A2/B1 enhances HIV-1 transcription by unfolding LTR promoter G-quadruplexes

G-quadruplexes are four-stranded conformations of nucleic acids that act as cellular epigenetic regulators. A dynamic G-quadruplex forming region in the HIV-1 LTR promoter represses HIV-1 transcription when in the folded conformation. This activity is enhanced by nucleolin, which induces and stabili...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Scalabrin, Matteo, Frasson, Ilaria, Ruggiero, Emanuela, Perrone, Rosalba, Tosoni, Elena, Lago, Sara, Tassinari, Martina, Palù, Giorgio, Richter, Sara N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364415/
https://ncbi.nlm.nih.gov/pubmed/28338097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45244
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