Stability and dynamics of membrane-spanning DNA nanopores

Recently developed DNA-based analogues of membrane proteins have advanced synthetic biology. A fundamental question is how hydrophilic nanostructures reside in the hydrophobic environment of the membrane. Here, we use multiscale molecular dynamics (MD) simulations to explore the structure, stability...

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Udgivet i:Nat Commun
Main Authors: Maingi, Vishal, Burns, Jonathan R., Uusitalo, Jaakko J., Howorka, Stefan, Marrink, Siewert J., Sansom, Mark S. P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364398/
https://ncbi.nlm.nih.gov/pubmed/28317903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14784
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