Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA metabolism, including stress granules. Defects in stress granule homeostasis constitute a cornerstone of ALS/FTLD pathogenesis. Polar residues (...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Mol Cell
Glavni autori: Boeynaems, Steven, Bogaert, Elke, Kovacs, Denes, Konijnenberg, Albert, Timmerman, Evy, Volkov, Alex, Guharoy, Mainak, De Decker, Mathias, Jaspers, Tom, Ryan, Veronica H., Janke, Abigail M., Baatsen, Pieter, Vercruysse, Thomas, Kolaitis, Regina-Maria, Daelemans, Dirk, Taylor, J. Paul, Kedersha, Nancy, Anderson, Paul, Impens, Francis, Sobott, Frank, Schymkowitz, Joost, Rousseau, Frederic, Fawzi, Nicolas L., Robberecht, Wim, Van Damme, Philip, Tompa, Peter, Van Den Bosch, Ludo
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2017
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364369/
https://ncbi.nlm.nih.gov/pubmed/28306503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.02.013
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items