Elevated granzyme B(+) B-cell level in SIV-infection correlate with viral load and low CD4 T-cell count

Granzyme B-expressing (GrB(+)) B cells are thought to contribute to immune dysfunctions in HIV patients, but so far their exact role is unknown. This report demonstrates for the first time the existence of GrB(+) B cells in SIV-infected rhesus macaques, which represent the most commonly used nonhuma...

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Detalles Bibliográficos
Publicado en:Immunol Cell Biol
Main Authors: Kotb, Ahmad, Klippert, Antonina, Daskalaki, Maria, Sauermann, Ulrike, Stahl-Hennig, Christiane, Neumann, Berit
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
Assuntos:
Short Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364320/
https://ncbi.nlm.nih.gov/pubmed/27779180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2016.96
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