Defining the Ail Ligand-Binding Surface: Hydrophobic Residues in Two Extracellular Loops Mediate Cell and Extracellular Matrix Binding To Facilitate Yop Delivery

Yersinia pestis, the causative agent of plague, binds host cells to deliver cytotoxic Yop proteins into the cytoplasm that prevent phagocytosis and generation of proinflammatory cytokines. Ail is an eight-stranded β-barrel outer membrane protein with four extracellular loops that mediates cell bindi...

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Библиографические подробности
Опубликовано в: :Infect Immun
Главные авторы: Tsang, Tiffany M., Wiese, Jeffrey S., Alhabeil, Jamal A., Usselman, Lisa D., Thomson, Joshua J., Matti, Rafla, Kronshage, Malte, Maricic, Natalie, Williams, Shanedah, Sleiman, Naama H., Felek, Suleyman, Krukonis, Eric S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2017
Предметы:
Molecular Pathogenesis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364317/
https://ncbi.nlm.nih.gov/pubmed/28167671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01047-15
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