Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase

Type II DNA-topoisomerases (topo II) play a crucial role in the maintenance of DNA topology. Previously, fungi of the Alternaria genus were found to produce mycotoxins that target human topo II. These results implied the question why a fungus should produce secondary metabolites that target a human...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arch Toxicol
Prif Awduron: Jarolim, Katharina, Del Favero, Giorgia, Ellmer, Doris, Stark, Timo D., Hofmann, Thomas, Sulyok, Michael, Humpf, Hans-Ulrich, Marko, Doris
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Berlin Heidelberg 2016
Pynciau:
Biologics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364253/
https://ncbi.nlm.nih.gov/pubmed/27682608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1855-z
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