Polymeric nanoparticle-docetaxel for the treatment of advanced solid tumors: phase I clinical trial and preclinical data from an orthotopic pancreatic cancer model

We assessed the efficacy of the polymeric nanoparticle containing docetaxel (PNP-DTX) in preclinical mouse models and determined the maximum tolerated dose (MTD) through clinical study. Subcutaneous and orthotopic mouse models were dedicated. Tumor growth delay in orthotopic model and quantification...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Song, Si Yeol, Kim, Kyu-pyo, Jeong, Seong-Yun, Park, Jin, Park, Jaesook, Jung, Joohee, Chung, Hye Kyung, Lee, Sa-Won, Seo, Min Hyo, Lee, Jung-shin, Jung, Kyung Hae, Choi, Eun Kyung
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363590/
https://ncbi.nlm.nih.gov/pubmed/27764799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12668
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