Activation of endoplasmic reticulum stress promotes autophagy and apoptosis and reverses chemoresistance of human small cell lung cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway

OBJECTIVE: This study aims to investigate the effects of endoplasmic reticulum stress (ERS) on autophagy, apoptosis and chemoresistance of human small cell lung cancer (SCLC) cells via the PI3K/AKT/mTOR signaling pathway. RESULTS: The expressions of ERS-related proteins (PEAK, eIF2α and CHOP) up-reg...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yu, Xin-Shuang, Du, Juan, Fan, Yu-Jun, Liu, Feng-Jun, Cao, Li-Li, Liang, Ning, Xu, De-Guo, Zhang, Jian-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363552/
https://ncbi.nlm.nih.gov/pubmed/27765907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12718
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