Dasatinib modulates sensitivity to pemetrexed in malignant pleural mesothelioma cell lines

BACKGROUND: Thymidylate synthase (TS), one of the key enzymes for thymidine synthesis, is a target of pemetrexed (PEM), a key agent for the systemic therapy of malignant pleural mesothelioma (MPM) and its overexpression has been correlated to PEM-resistance. In MPM, experimental data report activati...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Monica, Valentina, Iacono, Marco Lo, Bracco, Enrico, Busso, Simone, Blasio, Laura Di, Primo, Luca, Peracino, Barbara, Papotti, Mauro, Scagliotti, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363531/
https://ncbi.nlm.nih.gov/pubmed/27391433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10428
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