Genomic profiling is predictive of response to cisplatin treatment but not to PI3K inhibition in bladder cancer patient-derived xenografts

PURPOSE: Effective systemic therapeutic options are limited for bladder cancer. In this preclinical study we tested whether bladder cancer gene alterations may be predictive of treatment response. EXPERIMENTAL DESIGN: We performed genomic profiling of two bladder cancer patient derived tumor xenogra...

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Publicat a:Oncotarget
Autors principals: Wei, Lei, Chintala, Sreenivasulu, Ciamporcero, Eric, Ramakrishnan, Swathi, Elbanna, May, Wang, Jianmin, Hu, Qiang, Glenn, Sean T., Murakami, Mitsuko, Liu, Lu, Gomez, Eduardo Cortes, Sun, Yuchen, Conroy, Jacob, Miles, Kiersten Marie, Malathi, Kullappan, Ramaiah, Sudha, Anbarasu, Anand, Woloszynska-Read, Anna, Johnson, Candace S., Conroy, Jeffrey, Liu, Song, Morrison, Carl D., Pili, Roberto
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Priority Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363516/
https://ncbi.nlm.nih.gov/pubmed/27823983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13062
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