Preconditioning-induced CXCL12 upregulation minimizes leukocyte infiltration after stroke in ischemia-tolerant mice

Repetitive hypoxic preconditioning creates long-lasting, endogenous protection in a mouse model of stroke, characterized by reductions in leukocyte–endothelial adherence, inflammation, and infarct volumes. The constitutively expressed chemokine CXCL12 can be upregulated by hypoxia and limits leukocy...

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Bibliografiske detaljer
Udgivet i:J Cereb Blood Flow Metab
Main Authors: Selvaraj, Uma Maheswari, Ortega, Sterling B, Hu, Ruilong, Gilchrist, Robert, Kong, Xiangmei, Partin, Alexander, Plautz, Erik J, Klein, Robyn S, Gidday, Jeffrey M, Stowe, Ann M
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2016
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363460/
https://ncbi.nlm.nih.gov/pubmed/27006446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16639327
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