Efficient Presentation of Multiple Endogenous Epitopes to Both CD4(+) and CD8(+) Diabetogenic T Cells for Tolerance

Antigen-specific immunotherapy of type 1 diabetes, typically via delivery of a single native β cell antigen, has had little clinical benefit to date. With increasing evidence that diabetogenic T cells react against multiple β cell antigens, including previously unappreciated neo-antigens that can be...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Dastagir, Shamael R., Postigo-Fernandez, Jorge, Xu, Chunliang, Stoeckle, James H., Firdessa-Fite, Rebuma, Creusot, Rémi J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363322/
https://ncbi.nlm.nih.gov/pubmed/28344989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2016.12.002
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