Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

BACKGROUND: Normal myoepithelial cells (MECs) play an important tumour-suppressor role in the breast but display an altered phenotype in ductal carcinoma in situ (DCIS), gaining tumour-promoter functions. Matrix metalloproteinase-8 (MMP-8) is expressed by normal MECs but is lost in DCIS. This study...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Sarper, Muge, Allen, Michael D., Gomm, Jenny, Haywood, Linda, Decock, Julie, Thirkettle, Sally, Ustaoglu, Ahsen, Sarker, Shah-Jalal, Marshall, John, Edwards, Dylan R., Jones, J. Louise
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363009/
https://ncbi.nlm.nih.gov/pubmed/28330493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-017-0822-9
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