Valproic acid inhibits glioblastoma multiforme cell growth via paraoxonase 2 expression

We studied the potential mechanisms of valproic acid (VPA) in the treatment of glioblastoma multiforme (GBM). Using the human U87, GBM8401, and DBTRG-05MG GBM-derived cell lines, VPA at concentrations of 5 to 20 mM induced G2/M cell cycle arrest and increased the production of reactive oxygen specie...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Tseng, Jen-Ho, Chen, Cheng-Yi, Chen, Pei-Chun, Hsiao, Sheng-Huang, Fan, Chi-Chen, Liang, Yu-Chih, Chen, Chie-Pein
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362434/
https://ncbi.nlm.nih.gov/pubmed/28108734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14716
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