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KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species
KLK6 is a serine protease highly expressed in the nervous system. In synucleinopathies, including Parkinson disease, the levels of KLK6 inversely correlate with α-synuclein in CSF. Recently, we suggested that recombinant KLK6 mediates the degradation of extracellular α-synuclein directly and via a p...
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| Publicat a: | Oncotarget |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Impact Journals LLC
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5362421/ https://ncbi.nlm.nih.gov/pubmed/27845893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13264 |
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