CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility

We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male subfertility. Normally distributed in linear qua...

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Pubblicato in:eLife
Autori principali: Chung, Jean-Ju, Miki, Kiyoshi, Kim, Doory, Shim, Sang-Hee, Shi, Huanan F, Hwang, Jae Yeon, Cai, Xinjiang, Iseri, Yusuf, Zhuang, Xiaowei, Clapham, David E
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
Soggetti:
Biophysics and Structural Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362262/
https://ncbi.nlm.nih.gov/pubmed/28226241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23082
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