Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry

Severe bradycardia/bradyarrhythmia following coadministration of the HCV-NS5B prodrug sofosbuvir with amiodarone was recently reported. Our previous preclinical in vivo experiments demonstrated that only certain HCV-NS5B prodrugs elicit bradycardia when combined with amiodarone. In this study, we ev...

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Publicat a:Sci Rep
Autors principals: Lagrutta, Armando, Regan, Christopher P., Zeng, Haoyu, Imredy, John P., Koeplinger, Kenneth, Morissette, Pierre, Liu, Liping, Wollenberg, Gordon, Brynczka, Christopher, Lebrón, José, DeGeorge, Joseph, Sannajust, Frederick
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361079/
https://ncbi.nlm.nih.gov/pubmed/28327633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44820
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