Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.

There is little information regarding the molecular mechanisms of hepatocarcinogenesis. We studied the p53 gene at the DNA, RNA, and protein level in seven human hepatocellular carcinoma (HCC)-derived cell lines; six of seven showed p53 abnormalities. By Southern blotting, the p53 gene was found to...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Bressac, B, Galvin, K M, Liang, T J, Isselbacher, K J, Wands, J R, Ozturk, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53607/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2155427/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.5.1973
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