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Overexpression of c-Jun contributes to sorafenib resistance in human hepatoma cell lines

BACKGROUND: Despite recent advances in treatment strategies, it is still difficult to cure patients with hepatocellular carcinoma (HCC). Sorafenib is the only approved multiple kinase inhibitor for systemic chemotherapy in patients with advanced HCC. The majority of advanced HCC patients are resista...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Haga, Yuki, Kanda, Tatsuo, Nakamura, Masato, Nakamoto, Shingo, Sasaki, Reina, Takahashi, Koji, Wu, Shuang, Yokosuka, Osamu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360329/
https://ncbi.nlm.nih.gov/pubmed/28323861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174153
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