FGF21 Mediates the Thermogenic and Insulin-Sensitizing Effects of Dietary Methionine Restriction but Not Its Effects on Hepatic Lipid Metabolism

Dietary methionine restriction (MR) produces a rapid and persistent remodeling of white adipose tissue (WAT), an increase in energy expenditure (EE), and enhancement of insulin sensitivity. Recent work established that hepatic expression of FGF21 is robustly increased by MR. Fgf21(−/−) mice were use...

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Bibliografiske detaljer
Udgivet i:Diabetes
Main Authors: Wanders, Desiree, Forney, Laura A., Stone, Kirsten P., Burk, David H., Pierse, Alicia, Gettys, Thomas W.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2017
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360300/
https://ncbi.nlm.nih.gov/pubmed/28096260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1212
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