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Combined tRNA modification defects impair protein homeostasis and synthesis of the yeast prion protein Rnq1

Modified nucleosides in tRNA anticodon loops such as 5-methoxy-carbonyl-methyl-2-thiouridine (mcm(5)s(2)U) and pseuduridine (Ψ) are thought to be required for an efficient decoding process. In Saccharomyces cerevisiae, the simultaneous presence of mcm(5)s(2)U and Ψ38 in tRNA(Gln)(UUG) was shown to m...

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Bibliografiske detaljer
Udgivet i:Prion
Main Authors: Schaffrath, Raffael, Klassen, Roland
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360143/
https://ncbi.nlm.nih.gov/pubmed/28281930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2017.1284734
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