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Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy

BACKGROUND: Apolipoprotein E (ApoE) is a multifunctional protein, and its deficiency leads to the development of atherosclerosis in mice. Patients with pulmonary hypertension (PH) have reduced expression of ApoE in lung tissue. ApoE is known to inhibit endothelial and smooth muscle cell proliferatio...

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Vydáno v:Biol Sex Differ
Hlavní autoři: Umar, Soban, Partow-Navid, Rod, Ruffenach, Gregoire, Iorga, Andrea, Moazeni, Shayan, Eghbali, Mansoureh
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360087/
https://ncbi.nlm.nih.gov/pubmed/28344760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13293-017-0129-7
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