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Aflatoxin B(1) inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma

BACKGROUND: Aflatoxin B(1) (AFB(1)) contamination of food is very high in most sub-Saharan African countries. AFB(1) is known to cause hepatocellular carcinoma (HCC) by inducing mutation in the tumour suppressor gene TP53. The number of new HCC cases is high in West Africa with an accompanying high...

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Bibliografske podrobnosti
izdano v:Infect Agent Cancer
Main Authors: Narkwa, Patrick W., Blackbourn, David J., Mutocheluh, Mohamed
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360051/
https://ncbi.nlm.nih.gov/pubmed/28344639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13027-017-0127-8
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