TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours

BACKGROUND: TRIM8 plays a key role in controlling the p53 molecular switch that sustains the transcriptional activation of cell cycle arrest genes and response to chemotherapeutic drugs. The mechanisms that regulate TRIM8, especially in cancers like clear cell Renal Cell Carcinoma (ccRCC) and colore...

Full description

Saved in:
Bibliographic Details
Published in:Mol Cancer
Main Authors: Mastropasqua, Francesca, Marzano, Flaviana, Valletti, Alessio, Aiello, Italia, Di Tullio, Giuseppe, Morgano, Annalisa, Liuni, Sabino, Ranieri, Elena, Guerrini, Luisa, Gasparre, Giuseppe, Sbisà, Elisabetta, Pesole, Graziano, Moschetta, Antonio, Caratozzolo, Mariano Francesco, Tullo, Apollonia
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359838/
https://ncbi.nlm.nih.gov/pubmed/28327152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0634-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items