Analysis of monocyte infiltration in MPTP mice reveals that microglial CX3CR1 protects against neurotoxic over-induction of monocyte-attracting CCL2 by astrocytes

BACKGROUND: Evidence from mice suggests that brain infiltrating immune cells contribute to neurodegeneration, and we previously identified a deleterious lymphocyte infiltration in Parkinson’s disease mice. However, this remains controversial for monocytes, due to artifact-prone techniques used to di...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Parillaud, Vincent R., Lornet, Guillaume, Monnet, Yann, Privat, Anne-Laure, Haddad, Andrei T., Brochard, Vanessa, Bekaert, Amaury, de Chanville, Camille Baudesson, Hirsch, Etienne C., Combadière, Christophe, Hunot, Stéphane, Lobsiger, Christian S.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359822/
https://ncbi.nlm.nih.gov/pubmed/28320442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0830-9
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