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The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
Although limiting energy availability extends lifespan in many organisms, it is not understood how lifespan is coupled to energy levels. We find that the AMP:ATP ratio, a measure of energy levels, increases with age in Caenorhabditis elegans and can be used to predict life expectancy. The C. elegans...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC535911/ https://ncbi.nlm.nih.gov/pubmed/15574588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1255404 |
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