Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans

Chronic inflammation, a decline in immune responsiveness, and reduced cardiovascular function are all associated with aging, but the relationships among these phenomena remain unclear. Here, we longitudinally profiled a total of 84 signaling conditions in 91 young and older adults and observed an ag...

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Veröffentlicht in:Cell Syst
Hauptverfasser: Shen-Orr, Shai S., Furman, David, Kidd, Brian A., Hadad, Francois, Lovelace, Patricia, Huang, Ying-Wen, Rosenberg-Hasson, Yael, Mackey, Sally, Gomari Grisar, Fatemeh A., Pickman, Yishai, Maecker, Holden T., Chien, Yueh-hsiu, Dekker, Cornelia L., Wu, Joseph C., Butte, Atul J., Davis, Mark M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358544/
https://ncbi.nlm.nih.gov/pubmed/27746093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.09.009
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