Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells

A self-organizing organoid model provides a new approach to study the mechanism of human liver organogenesis. Previous animal models documented that simultaneous paracrine signaling and cell-to-cell surface contact regulate hepatocyte differentiation. To dissect the relative contributions of the par...

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Enregistré dans:
Détails bibliographiques
Publié dans:Development
Auteurs principaux: Asai, Akihiro, Aihara, Eitaro, Watson, Carey, Mourya, Reena, Mizuochi, Tatsuki, Shivakumar, Pranavkumar, Phelan, Kieran, Mayhew, Christopher, Helmrath, Michael, Takebe, Takanori, Wells, James, Bezerra, Jorge A.
Format: Artigo
Langue:Inglês
Publié: The Company of Biologists Ltd 2017
Sujets:
Human Development
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358109/
https://ncbi.nlm.nih.gov/pubmed/28275009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.142794
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