DNA methylation signatures in peripheral blood strongly predict all-cause mortality

DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we performed epigenome-wide screening and validation to identify mortality-related DNAm signatures in a general population-based cohort with up to 14 years follow-up. In the discovery panel in a case-cohort approach, 1...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Yan, Wilson, Rory, Heiss, Jonathan, Breitling, Lutz P., Saum, Kai-Uwe, Schöttker, Ben, Holleczek, Bernd, Waldenberger, Melanie, Peters, Annette, Brenner, Hermann
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357865/
https://ncbi.nlm.nih.gov/pubmed/28303888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14617
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