Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration

Tau protein inclusions are a frequent hallmark of a variety of neurodegenerative disorders. The 10+16 intronic mutation in MAPT gene, encoding tau, causes frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), by altering the splicing of the gene and inducing an increase in the...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Esteras, Noemí, Rohrer, Jonathan D., Hardy, John, Wray, Selina, Abramov, Andrey Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357682/
https://ncbi.nlm.nih.gov/pubmed/28319892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.03.008
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