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A method for identifying genetic heterogeneity within phenotypically-defined disease subgroups
Many common diseases show wide phenotypic variation. We present a statistical method for determining whether phenotypically defined subgroups of disease cases represent different genetic architectures, in which disease-associated variants have different effect sizes in the two subgroups. Our method...
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| Publicado en: | Nat Genet |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5357574/ https://ncbi.nlm.nih.gov/pubmed/28024155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3751 |
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