Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells

We developed an allele-specific assay for transposase-accessible chromatin with high-throughput sequencing (ATAC–seq) to genotype and profile active regulatory DNA across the genome. Using a mouse hybrid F(1) system, we found that monoallelic DNA accessibility across autosomes was pervasive, develop...

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Bibliographic Details
Published in:Nat Genet
Main Authors: Xu, Jin, Carter, Ava C, Gendrel, Anne-Valerie, Attia, Mikael, Loftus, Joshua, Greenleaf, William J, Tibshirani, Robert, Heard, Edith, Chang, Howard Y
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357084/
https://ncbi.nlm.nih.gov/pubmed/28112738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3769
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