Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential

BACKGROUND: Nanobodies, named as VHHs (variable domain of heavy chain of HCAb [heavy-chain antibodies]), are derived from heavy-chain-only antibodies that circulate in sera of camelids. Their exceptional physicochemical properties, possibility of humanization, and unique antigen recognition properti...

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Detalles Bibliográficos
Publicado en:Int J Nanomedicine
Main Authors: Yu, Yuan, Li, Jialu, Zhu, Xuejun, Tang, Xiaowen, Bao, Yangyi, Sun, Xiang, Huang, Yuhui, Tian, Fang, Liu, Xiaomei, Yang, Lin
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2017
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357075/
https://ncbi.nlm.nih.gov/pubmed/28331319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S127575
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