A mammalian artificial chromosome engineering system (ACE System) applicable to biopharmaceutical protein production, transgenesis and gene-based cell therapy

Mammalian artificial chromosomes (MACs) provide a means to introduce large payloads of genetic information into the cell in an autonomously replicating, non-integrating format. Unique among MACs, the mammalian satellite DNA-based Artificial Chromosome Expression (ACE) can be reproducibly generated d...

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Detalhes bibliográficos
Main Authors: Lindenbaum, Michael, Perkins, Ed, Csonka, Erika, Fleming, Elena, Garcia, Lisa, Greene, Amy, Gung, Lindsay, Hadlaczky, Gyula, Lee, Edmond, Leung, Josephine, MacDonald, Neil, Maxwell, Alexisann, Mills, Kathleen, Monteith, Diane, Perez, Carl F., Shellard, Joan, Stewart, Sandy, Stodola, Tom, Vandenborre, Dana, Vanderbyl, Sandy, Ledebur, Harry C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
Assuntos:
NAR Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC535698/
https://ncbi.nlm.nih.gov/pubmed/15585659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnh169
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