The implication of FLT3 amplification for FLT targeted therapeutics in solid tumors

We investigated the patients with solid cancers harboring Fms-like tyrosine kinase 3 (FLT3) amplification using targeted sequencing of tumor tissue specimen and FISH assay. Simultaneously, FLT3-amplified patient-derived cells (PDCs) were generated to evaluate the sensitivity to FLT3 inhibition. A pa...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lim, Sung Hee, Kim, Sun-Young, Kim, Kyung, Jang, Hyojin, Ahn, Soomin, Kim, Kyoung-Mee, Kim, Nayoung K.D., Park, Woongyang, Lee, Su Jin, Kim, Seung Tae, Park, Se Hoon, Park, Joon Oh, Park, Young Suk, Lee, Se-Hoon, Lim, Ho Yeong, Park, Keunchil, Kang, Won Ki, Lee, Jeeyun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356878/
https://ncbi.nlm.nih.gov/pubmed/27906677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13700
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