H(2)O(2) treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway

Naked mole-rats (NMR; Heterocephalus glaber) display extreme longevity and resistance to cancer. Here, we examined whether autophagy contributes to the longevity of NMRs by assessing the effects of the PI3K/Akt pathway inhibitor LY294002 and the autophagy inhibitor chloroquine (CQ) on autophagy and...

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Pubblicato in:Oncotarget
Autori principali: Zhao, Shanmin, Li, Li, Wang, Shiyong, Yu, Chenlin, Xiao, Bang, Lin, Lifang, Cong, Wei, Cheng, Jishuai, Yang, Wenjing, Sun, Wei, Cui, Shufang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356702/
https://ncbi.nlm.nih.gov/pubmed/27863375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13321
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