Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer

Platelet-derived growth factor (PDGF) and signaling via its receptors plays a crucial role in tumor cell proliferation and thus may represent an attractive target besides VEGF/EGFR-based antibody therapies. In this study we analyzed the influence of PDGF in colorectal cancer. PDGF was expressed inte...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Moench, Romana, Grimmig, Tanja, Kannen, Vinicius, Tripathi, Sudipta, Faber, Marc, Moll, Eva-Maria, Chandraker, Anil, Lissner, Reinhard, Germer, Christoph-Thomas, Waaga-Gasser, Ana Maria, Gasser, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356587/
https://ncbi.nlm.nih.gov/pubmed/27626684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11899
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