Specific inhibition of p110α subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers

Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide. It is often associated with activating mutations in KRAS leading to deregulation of major signaling pathways as the RAS-RAF-MAPK and PI3K-Akt. However, the therapeutic options for CRC patients harboring somatic KRAS mutations...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Fernandes, Maria Sofia, Melo, Soraia, Velho, Sérgia, Carneiro, Patrícia, Carneiro, Fátima, Seruca, Raquel
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356572/
https://ncbi.nlm.nih.gov/pubmed/27602501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11843
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