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Using Local States To Drive the Sampling of Global Conformations in Proteins

[Image: see text] Conformational changes associated with protein function often occur beyond the time scale currently accessible to unbiased molecular dynamics (MD) simulations, so that different approaches have been developed to accelerate their sampling. Here we investigate how the knowledge of ba...

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Detalhes bibliográficos
Publicado no:J Chem Theory Comput
Main Authors: Pandini, Alessandro, Fornili, Arianna
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356493/
https://ncbi.nlm.nih.gov/pubmed/26808351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jctc.5b00992
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