Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice

Iron availability for erythropoiesis and its dysregulation in β-thalassemia are incompletely understood. We previously demonstrated that exogenous apotransferrin leads to more effective erythropoiesis, decreasing erythroferrone (ERFE) and derepressing hepcidin in β-thalassemic mice. Transferrin-boun...

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Vydáno v:Blood
Hlavní autoři: Li, Huihui, Choesang, Tenzin, Bao, Weili, Chen, Huiyong, Feola, Maria, Garcia-Santos, Daniel, Li, Jie, Sun, Shuming, Follenzi, Antonia, Pham, Petra, Liu, Jing, Zhang, Jinghua, Ponka, Prem, An, Xiuli, Mohandas, Narla, Fleming, Robert E., Rivella, Stefano, Li, Guiyuan, Ginzburg, Yelena Z.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2017
Témata:
Red Cells, Iron, and Erythropoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356456/
https://ncbi.nlm.nih.gov/pubmed/28151426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-09-742387
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