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Transgenic mice expressing a soluble foreign H-2 class I antigen are tolerant to allogeneic fragments presented by self class I but not to the whole membrane-bound alloantigen.

The properties of transmembrane and soluble transplantation antigens were compared with respect to the induction of tolerance and the selection of the T-cell repertoire. For this purpose, transgenic (H-2b x H-2d)F1 mice were constructed that carry integrated copies of a modified H-2Kk gene resulting...

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Библиографические подробности
Главные авторы: Arnold, B, Messerle, M, Jatsch, L, Küblbeck, G, Koszinowski, U
Формат: Artigo
Язык:Inglês
Опубликовано: 1990
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC53563/
https://ncbi.nlm.nih.gov/pubmed/2308936
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