Nitric oxide production is stimulated by bitter taste receptors ubiquitously expressed in the sinonasal cavity

BACKGROUND: Bitter taste receptors (T2R) have recently been demonstrated to contribute to sinonasal innate immunity. One T2R, T2R38, regulates mucosal defense against gram-negative organisms through nitric oxide (NO) production, which enhances mucociliary clearance and directly kills bacteria. To de...

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Publicado en:Am J Rhinol Allergy
Autores principales: Yan, Carol H., Hahn, Samuel, McMahon, Derek, Bonislawski, David, Kennedy, David W., Adappa, Nithin D., Palmer, James N., Jiang, Peihua, Lee, Robert J., Cohen, Noam A.
Formato: Artigo
Lenguaje:Inglês
Publicado: OceanSide Publications, Inc. 2017
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356199/
https://ncbi.nlm.nih.gov/pubmed/28452704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2500/ajra.2017.31.4424
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