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Directed Evolution of Key Residues in Fluorescent Protein Inverses the Polarity of Voltage Sensitivity in the Genetically Encoded Indicator ArcLight
[Image: see text] Genetically encoded calcium indicators (GECIs) produce unprecedentedly large signals that have enabled routine optical recording of single neuron activity in vivo in rodent brain. Genetically encoded voltage indicators (GEVIs) offer a more direct measure of neuronal electrical stat...
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| Published in: | ACS Chem Neurosci |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Chemical
Society
2017
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5355904/ https://ncbi.nlm.nih.gov/pubmed/28045247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00234 |
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