Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells

Familial hypercholesterolemia (FH) causes elevation of low-density lipoprotein cholesterol (LDL-C) in blood and carries an increased risk of early-onset cardiovascular disease. A caveat for exploration of new therapies for FH is the lack of adequate experimental models. We have created a comprehensi...

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Publicado no:Stem Cell Reports
Main Authors: Yang, Jiayin, Wang, Yu, Zhou, Ting, Wong, Lai-Yung, Tian, Xiao-Yu, Hong, Xueyu, Lai, Wing-Hon, Au, Ka-Wing, Wei, Rui, Liu, Yuqing, Cheng, Lai-Hung, Liang, Guichan, Huang, Zhijian, Fan, Wenxia, Zhao, Ping, Wang, Xiwei, Ibañez, David P., Luo, Zhiwei, Li, Yingying, Zhong, Xiaofen, Chen, Shuhan, Wang, Dongye, Li, Li, Lai, Liangxue, Qin, Baoming, Bao, Xichen, Hutchins, Andrew P., Siu, Chung-Wah, Huang, Yu, Esteban, Miguel A., Tse, Hung-Fat
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355732/
https://ncbi.nlm.nih.gov/pubmed/28262545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.01.027
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