Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines

Giardia duodenalis is an intestinal parasite that causes 200–300 million episodes of diarrhoea annually. Metronidazole (Mtz) is a front-line anti-giardial, but treatment failure is common and clinical resistance has been demonstrated. Mtz is thought to be activated within the parasite by oxidoreduct...

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Udgivet i:Front Microbiol
Main Authors: Ansell, Brendan R. E., Baker, Louise, Emery, Samantha J., McConville, Malcolm J., Svärd, Staffan G., Gasser, Robin B., Jex, Aaron R.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355454/
https://ncbi.nlm.nih.gov/pubmed/28367140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.00398
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