The EMSY threonine 207 phospho-site is required for EMSY-driven suppression of DNA damage repair

BRCA1 and BRCA2 are essential for the repair of double-strand DNA breaks, and alterations in these genes are a hallmark of breast and ovarian carcinomas. Other functionally related genes may also play important roles in carcinogenesis. Amplification of EMSY, a putative BRCAness gene, has been sugges...

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Publicado en:Oncotarget
Autores principales: Jelinic, Petar, Eccles, Laura A., Tseng, Jill, Cybulska, Paulina, Wielgos, Monicka, Powell, Simon N., Levine, Douglas A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
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Priority Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355139/
https://ncbi.nlm.nih.gov/pubmed/28099152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14637
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