MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling

Ultra Violet (UV)-caused skin cell damage is a main cause of skin cancer. Here, we studied the activity of MHY1485, a mTOR activator, in UV-treated skin cells. In primary human skin keratinocytes, HaCaT keratinocytes and human skin fibroblasts, MHY1485 ameliorated UV-induced cell death and apoptosis...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Yang, Bo, Xu, Qiu-Yun, Guo, Chun-Yan, Huang, Jin-Wen, Wang, Shu-Mei, Li, Yong-Mei, Tu, Ying, He, Li, Bi, Zhi-Gang, Ji, Chao, Cheng, Bo
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355053/
https://ncbi.nlm.nih.gov/pubmed/28061443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14299
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