Alternative lengthening of telomeres in primary pancreatic neuroendocrine neoplasms is associated with aggressive clinical behavior and poor survival

PURPOSE: Alternative lengthening of telomeres (ALT), a telomerase-independent telomere maintenance mechanism, is strongly associated with ATRX and DAXX alterations and occurs frequently in pancreatic neuroendocrine tumors (PanNETs). EXPERIMENTAL DESIGN: In a Korean cohort of 269 surgically resected...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Kim, Joo Young, Brosnan-Cashman, Jacqueline A., An, Soyeon, Kim, Sung Joo, Song, Ki-Byung, Kim, Min-Sun, Kim, Mi-Ju, Hwang, Dae Wook, Meeker, Alan K., Yu, Eunsil, Kim, Song Cheol, Hruban, Ralph H., Heaphy, Christopher M., Hong, Seung-Mo
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354973/
https://ncbi.nlm.nih.gov/pubmed/27663587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1147
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