MSH2/BRCA1 expression as a DNA-repair signature predicting survival in early–stage lung cancer patients from the IFCT-0002 Phase 3 Trial

INTRODUCTION: DNA repair is a double-edged sword in lung carcinogenesis. When defective, it promotes genetic instability and accumulated genetic alterations. Conversely these defects could sensitize cancer cells to therapeutic agents inducing DNA breaks. METHODS: We used immunohistochemistry (IHC) t...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Levallet, Guénaëlle, Dubois, Fatéméh, Fouret, Pierre, Antoine, Martine, Brosseau, Solenn, Bergot, Emmanuel, Beau-Faller, Michèle, Gounant, Valérie, Brambilla, Elisabeth, Debieuvre, Didier, Molinier, Olivier, Galateau-Sallé, Françoise, Mazieres, Julien, Quoix, Elisabeth, Pujol, Jean-Louis, Moro-Sibilot, Denis, Langlais, Alexandra, Morin, Franck, Westeel, Virginie, Zalcman, Gérard
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354834/
https://ncbi.nlm.nih.gov/pubmed/28008145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14025
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