The JAZF1-SUZ12 fusion protein disrupts PRC2 complexes and impairs chromatin repression during human endometrial stromal tumorogenesis

The Polycomb repressive complex 2 (PRC2), which contains three core proteins EZH2, EED and SUZ12, controls chromatin compaction and transcription repression through trimethylation of lysine 27 on histone 3. The (7;17)(p15;q21) chromosomal translocation present in most cases of endometrial stromal sa...

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Vydáno v:Oncotarget
Hlavní autoři: Ma, Xianyong, Wang, Jinglan, Wang, Jianhui, Ma, Charles X., Gao, Xiaobin, Patriub, Vytas, Sklar, Jeffrey L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354813/
https://ncbi.nlm.nih.gov/pubmed/27845897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13270
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